The right back, 26, has penned a deal that will keep him at Molineux until June 2023, with an option to extend it to June 2025.
“FC Barcelona would like to publicly express their gratitude to Nélson Semedo for his commitment and dedication and wishes him all the best for the future,” the Spanish club said in a statement.
Semedo joins Wolves as a replacement for Matt Doherty, who joined Tottenham Hotspur on a four-year contract. At Wolves, he will link up with a sizeable Portuguese contingent that includes Fabio Silva, Joao Moutinho, Ruben Neves and Rui Patricio.
“It isn’t often that we have the opportunity to sign a world-class player from a world-class club. Nelson’s signing shows we will never stop progressing and we are still hungry and humble in our heart,” Wolves chairman Jeff Shi said.
Semedo’s signing follows the arrivals of Silva, Matija Sarkic, Fernando Marcal, Vitinha and Ki-Jana Hoever.