The 24-year-old defender will undergo keyhole surgery on his left knee on Wednesday to determine how long he will be out for.
The injury rules him out of Tuesday’s Champions League home match against Turkish side Basaksehir.
He set up Leon Goretzka’s winning header from the right wing in a 2-1 away win against Ukraine in the Nations League, then switched to right-back for the 3-3 draw with Switzerland.